VISDB Viral Integration Site DataBase

VIS ID

TVIS10011654

Fusion event

HBV-DMD integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2298

Orient

+

Integrated sequence

ACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTAT| |AGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGAC

Chromosome

chrX

Cytoband

p21.1

Reference genome

Start

End

32443354/32425237 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-31-5p ; hsa-mir-155-5p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-4446-5p ; hsa-mir-186-3p ; hsa-mir-561-3p ; hsa-mir-6499-3p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-297 ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-8068 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-511-3p ; hsa-mir-9-3p

Nearest miRNA

hsa-mir-23c/Upstream/2850879; hsa-let-7f-2/Downstream/158419;

Nearest TSS

Nearest CpG islands

None/Target, chrX-CpG: 62/Upstream/1158335, chrX-CpG: 36/Downstream/1301076

Nearest cancer related gene

DMD(TSG, No orient, 0)

Upstream sequence

aatacccaataataggattgctgtgtcaaattgtagttctgttttaagttctttgagatatcacaaaactgctttccacagagattgaatttacattccc

Downstream sequence

AGAGTCCTAAACAACCTGAAAACAGAGTTACCTACTTCTCAGGGATAAATTTATCCTTGGTGGATAAACTTTCTCAAACTTACTACTCTCCACCTCAGAA