Basic Information
VIS ID
TVIS10011655
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1793
Orient
-
Integrated sequence
GACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATA| |AATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGG
Host Sequence
Chromosome
chrX
Cytoband
p11.3
Reference genome
GRCh37/hg19
Start
43449016/43589768 (Hg38)
End
43449016/43589768 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1587/Upstream/3752155; hsa-let-7f-2/Downstream/2156389;
Nearest TSS
ENST00000429181/Upstream/412774; ENST00000497485/Downstream/65139;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/811512, chrX-CpG: 54/Downstream/65014
Nearby gene
PPP1R2C(-811530) ; MAOA(+65139) ;
Upstream sequence
AGGGCTCATCCCCTGTACATCAGCTAGCAGGTTGGCAGCAAGACCAATCCCAGGCTGTGGCTGCTGGAGGAACAGGAGAAATCATGGGTTTCTGCCTTGG
Downstream sequence
TCTAAGTTCTAACAGTACTGCAAGCAGGAAAACCTGAGGTCGTTAGTGCTTTGCAAATGAGGAAACCCAGGATAAAAAGCTTACTTGAGTCCTAACCGTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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