Basic Information
VIS ID
TVIS10011656
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1811
Orient
+
Integrated sequence
AAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAG| |CACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC
Host Sequence
Chromosome
chrX
Cytoband
p22.31
Reference genome
GRCh37/hg19
Start
7338962/7420921 (Hg38)
End
7338962/7420921 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRAXB
Nearest miRNA
hsa-mir-3690-1/Upstream/272984; hsa-let-7f-2/Downstream/706044;
Nearest TSS
ENST00000429181/Upstream/201465; ENST00000341408/Downstream/421341;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/272474, chrX-CpG: 49/Downstream/506115
Nearby gene
STS(-66280) ; VCX(+471341) ;
Upstream sequence
TGTACATCAGCTAGCAGGTTGGCAGCAAGACCAATCCCAGGCTGTGGCTGCTGGAGGAACAGGAGAAATCATGGGTTTCTGCCTTGGCCAGCCCCAACTC
Downstream sequence
TTGCCATAGCAACAGTTGCTTGGATACATTTACTACAGTAGTTACCAcctctgttctgctgcttttcctaagacactttttctgcctttttttttctctt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate