Basic Information
VIS ID
TVIS10011657
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1069
Orient
-
Integrated sequence
GGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGC| |ATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCA
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
53654809/53362612 (Hg38)
End
53654809/53362612 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/1085412; hsa-mir-11181/Downstream/2010328;
Nearest TSS
ENST00000557528/Upstream/246247; ENST00000561210/Downstream/178468;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/556333, chr15-CpG: 33/Downstream/396846
Nearby gene
ONECUT1(-572600) ; WDR72(+151129) ;
Nearest cancer related gene
ONECUT1(TSG, -572600) ;
Upstream sequence
ACAGAGGCCTCGGGAAGGGGCCATTTTAGGAGACAGACAGCAGGACTCTAGGAAATTATCACTAACTTCAGAAAAGCAATGGAATTCTGGGGAAGAGATC
Downstream sequence
CCATTGAAAGAGGCAGCACAGGCAGCTTGTGAGCAAGTCAGGGCCAAAGAAGCAGAAGGTCTGTGCAAGGGAAATATTGCCCCCTGCCCCTGCCCCCCGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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