Basic Information
VIS ID
TVIS10011658
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
53654812/53362615 (Hg38)
End
53654812/53362615 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/1085415; hsa-mir-11181/Downstream/2010325;
Nearest TSS
ENST00000557528/Upstream/246250; ENST00000561210/Downstream/178465;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/556336, chr15-CpG: 33/Downstream/396843
Nearby gene
ONECUT1(-572603) ; WDR72(+151126) ;
Nearest cancer related gene
ONECUT1(TSG, -572603) ;
Upstream sequence
GAGGCCTCGGGAAGGGGCCATTTTAGGAGACAGACAGCAGGACTCTAGGAAATTATCACTAACTTCAGAAAAGCAATGGAATTCTGGGGAAGAGATCCCA
Downstream sequence
TTGAAAGAGGCAGCACAGGCAGCTTGTGAGCAAGTCAGGGCCAAAGAAGCAGAAGGTCTGTGCAAGGGAAATATTGCCCCCTGCCCCTGCCCCCCGCCCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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