Basic Information
VIS ID
TVIS10011660
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
357
Orient
+
Integrated sequence
GTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCA| |ACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATC
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
21476919/21573655 (Hg38)
End
21476919/21573655 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/2229081; hsa-mir-10226/Downstream/5720255;
Nearest TSS
ENST00000595228/Upstream/21975; ENST00000567955/Downstream/803;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/21980, chr17-CpG: 19/Downstream/19185
Nearby gene
LINC02693(-21978) ; FAM27E5(+348451) ;
Upstream sequence
TGTTGCCGTCTCCCATTCCCGGCTTCCTCTTCAAGATTGTGTCATGGTGTGGCTTCATTTCGCAGAGAAGAGGCGTGGAAAGGTACAACCATCTTCTTGG
Downstream sequence
ACGTGGGTCTGCTCCTCTCCTGCCGGACAATGTGCTACCGTGGGGCTTTTGTCCTGGGCTGGAGTGTGGTCCTCTTGATCCTAGAAAAGAGGCCGCTCAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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