Basic Information
VIS ID
TVIS10011661
Fusion event
HBV-FLJ36000 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
357
Orient
+
Integrated sequence
GTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCA| |ACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATC
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
21909505/22410176 (Hg38)
End
21909505/22410176 (Hg38)
Orient
-
Location type
ncRNA_exonic
Target gene
FLJ36000
Nearest miRNA
hsa-mir-1180/Upstream/3065602; hsa-mir-10226/Downstream/4883734;
Nearest TSS
ENST00000595228/Upstream/4157; ENST00000562182/Downstream/9846;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/192655, chr17-CpG: 27/Downstream/25198
Upstream sequence
GAGCGTCCTCTTTTCTAGGATCAAGAGGACCACACTCCAGCCCAGGACAAATGCCCCACGGTAGCACATTGTCCGGCAGGAGAGGAGCAGACCCACGTCC
Downstream sequence
AAGAAGATGGTTGTACCTTTCCACGCCTCTTCTCTGCGAAATGAAGCCACAGAACGACACAATCTTGAAGAGGAAGCCGTGAATGGGAGACTGCAACAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate