Basic Information
VIS ID
TVIS10011666
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2439
Orient
-
Integrated sequence
TACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGG| |GAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCA
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
44902079/44860587 (Hg38)
End
44902079/44860587 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/746277; hsa-let-7g/Downstream/1301;
Nearest TSS
ENST00000440867/Upstream/17464; ENST00000302392/Downstream/1282;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/98461, chr3-CpG: 108/Downstream/880
Nearby gene
KIF15(-7331) ; MIR564(+1301) ;
Upstream sequence
TTATCTCATTGGTTTCACCAAATACGCACTTAAATCTTAGACATTATATAATTGAGAGAAAAAGGGAGCTCTCAGTTCCTATGATTTCTTGCTGGGCTAG
Downstream sequence
gtcttgaactcctgacctcgtaatccacccacctttggcctcccaaagtgctgggattacaggcgtgagccaccgtgcctggccTTATCCGTGCttttat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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