Basic Information
VIS ID
TVIS10011677
Fusion event
HBV-LOC105378314 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2354
Orient
-
Integrated sequence
ATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACG| |ACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAG
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
59579762/57820002 (Hg38)
End
59579762/57820002 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
LOC105378314
Nearest miRNA
hsa-mir-1265/Upstream/515443; hsa-mir-107/Downstream/5552955;
Nearest TSS
ENST00000439456/Upstream/1458727; ENST00000489785/Downstream/447932;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1458488, chr10-CpG: 34/Downstream/286619
Nearby gene
MIR3924(-515443) ; IPMK(+371516) ;
Upstream sequence
CAAAAGAAAGTTAATAGACATAATAAACAGCTTTCTGGTGCTGAACCTTAGATTTGGCTATTAAAACTTAGCTTTCAGATGACAAGTTAATCATGATAAT
Downstream sequence
TAATAGTAAGAACAATCATTTTTAATGGCGGGATCTATTTTTTCAGTTTTGGATGTCATGGGTCTATAATATGTAAGGGCTGACTGACGGAAATAATAGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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