Basic Information
VIS ID
TVIS10011680
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
994
Orient
+
Integrated sequence
GATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCA| |ACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTC
Host Sequence
Chromosome
chr7
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
129434110/129794270 (Hg38)
End
129434110/129794270 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/19256; hsa-mir-10399/Downstream/701841;
Nearest TSS
ENST00000635602/Upstream/9085; ENST00000480018/Downstream/45471;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/8251, chr7-CpG: 53/Downstream/31294
Nearby gene
MIR183(-19256) ; UBE2H(+36463) ;
Nearest cancer related gene
MIR183(OG, -19256) ;
Upstream sequence
TCATTCACTAGCTTGCTCTGAAACAAGTGACTCTACTCAAAATAGAAAGAATAAAATTTTGGAATTTGTTTAACAAGGGAAGCTTCCCCATTTGGAGTGA
Downstream sequence
gagcctgagatgacagcgtagttccacccacttcacaggtggggaaactgaggtgatggagagggtcagaagtaaTCCCTTTCAGCCCAGCAGGCACTGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate