Basic Information
VIS ID
TVIS10011681
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2490
Orient
-
Integrated sequence
TCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGG| |GCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAG
Host Sequence
Chromosome
chr7
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
129434139/129794299 (Hg38)
End
129434139/129794299 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/19285; hsa-mir-10399/Downstream/701812;
Nearest TSS
ENST00000635602/Upstream/9114; ENST00000480018/Downstream/45442;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/8280, chr7-CpG: 53/Downstream/31265
Nearby gene
MIR183(-19285) ; UBE2H(+36434) ;
Nearest cancer related gene
MIR183(OG, -19285) ;
Upstream sequence
ATATTTTAATGAGACTATTTCTCTTGGTTTTCTGATAAATGAGTTACTGGAACCCTTATGAATCTGAATGCAAAAGAAACAGCTaaatgttatgtaattg
Downstream sequence
acttcacaggtggggaaactgaggtgatggagagggtcagaagtaaTCCCTTTCAGCCCAGCAGGCACTGGGGAATTCTGAGCTCTGGGCTCCCAGGCCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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