Basic Information
VIS ID
TVIS10011685
Fusion event
HBV-LINC01122 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1934
Orient
+
Integrated sequence
GCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGC| |TACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCT
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
59140189/58913054 (Hg38)
End
59140189/58913054 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA2S
Target gene
LINC01122
Nearest miRNA
hsa-mir-1301/Upstream/2912259; hsa-mir-10b/Downstream/1474308;
Nearest TSS
ENST00000437798/Upstream/392301; ENST00000422793/Downstream/11548;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/484077, chr2-CpG: 103/Downstream/1547633
Upstream sequence
TATTGAAAGGACGTCAGACTCTTGAAATGGTAAATAATGGAATAAAAATAAATAAAGGTACCTGTATTTTGACAGTGATATTCCACCTCTGGTTTCCCCA
Downstream sequence
TGCGCAAGCGTAAACACACActctctctctctctctccgtctctctctcACACACACAATCATTCAAATGCCTTTTCTTTCTCTGACAAAAATATTCATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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