Basic Information
VIS ID
TVIS10011687
Fusion event
HBV-LARGE1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
994
Orient
+
Integrated sequence
GATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCA| |ACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTC
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
33617115/33221129 (Hg38)
End
33617115/33221129 (Hg38)
Orient
-
Location type
Intronic
Target gene
LARGE1
miRNAs that regulate target gene
hsa-mir-18a-5p
Nearest miRNA
hsa-mir-1286/Upstream/1599598; hsa-let-7a-3/Downstream/215453;
Nearest TSS
ENST00000624155/Upstream/57066; ENST00000453924/Downstream/622;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/162661, chr22-CpG: 20/Downstream/429239
Nearby gene
SYN3(-162738) ; LARGE1(+51947) ;
Upstream sequence
GGAAGATTCCTGGGTTTCCCCCTCAGCACACCCTCCCCAGACACACCTGACGGCAAAAGCAGACATCCTCCTATCATTAAGAAACTTATAAAATTATAAT
Downstream sequence
GTCCTTCTATCTTCAGCTTAATACCTTGCCGTTGTTAAAAAGAGAGAGAGAGAGAGAGGGAATAACACAAAGGAATTAAGCAAAAGGCTATTTCCACACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate