Basic Information
VIS ID
TVIS10011689
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1806
Orient
-
Integrated sequence
ACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGC| |ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG
Host Sequence
Chromosome
chr5
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
25572773/25572664 (Hg38)
End
25572773/25572664 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5E
Nearest miRNA
hsa-mir-10397/Upstream/8416672; hsa-mir-103a-1/Downstream/6363438;
Nearest TSS
ENST00000502646/Upstream/126739; ENST00000514255/Downstream/827155;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/381660, chr5-CpG: 29/Downstream/336569
Nearby gene
LINC02239(-732081) ; CDH9(+1307936) ;
Upstream sequence
catccatcccctcatccatccaatcatccaccctttcatctatccatccatccactcacccacccatcattcaactatccacccaaccatccattcattc
Downstream sequence
aggtaattgtagccccttttatctaaatgtcttatgaaaatgggtactatatctaactgggggatgttttcccctttctagtactataaaactaaagaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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