Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011690
Fusion event
HBV-IKZF1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
505
Orient
+
Integrated sequence
CTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCA| |GCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTAT
Host Sequence
Chromosome
chr7
Cytoband
p12.2
Reference genome
Start
End
50421011/50353313 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-1183/Upstream/5471513; hsa-mir-10399/Downstream/6602472;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/48390, chr7-CpG: 79/Downstream/46555
Nearest cancer related gene
IKZF1(OG, No orient, 0)
Upstream sequence
atttatcaagaggcctgcagtccagggagtaaagagaagcagcgtttgtatgtgcagggaaggggaatggGTTAAAGGAAGGATCTCAGAGACTATTTAC
Downstream sequence
CCACACTCTTGCCATGATGAGCAGTTTCAGCCAAAAGCTCCTTCCCCTGCCCTAACACCTCCTGCAAGGCCTGAGGTCTGGAAGCCACCTGCGCCTGCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.