Basic Information
VIS ID
TVIS10011692
Fusion event
HBV-LOC105376103 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1859
Orient
+
Integrated sequence
TTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCC| |TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG
Host Sequence
Chromosome
chr9
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
82995204/80380289 (Hg38)
End
82995204/80380289 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105376103
Nearest miRNA
hsa-mir-101-2/Upstream/9570205; hsa-let-7a-1/Downstream/3589459;
Nearest TSS
ENST00000422679/Upstream/349710; ENST00000413050/Downstream/491006;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/806644, chr9-CpG: 255/Downstream/1306935
Nearby gene
TLE4(-653548) ; TLE1(+1203394) ;
Upstream sequence
tattctttccttcaatggatctaatagcctctgttctactttgaatgatattgagatttttgagcttccacatatgagtgagaatatacagtgtttaact
Downstream sequence
GTTAATTTTGTTCGAATCTTGAAAAGTCTAAATTCAGTTTTTGGCTCTGGTGCACCATGTGCCTGGGTTAATTTGGGTGGCTCAATCCCAAAGCAGCTCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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