Basic Information
VIS ID
TVIS10011693
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1376
Orient
-
Integrated sequence
GGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCA| |TGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCT
Host Sequence
Chromosome
chrX
Cytoband
p22.33
Reference genome
GRCh37/hg19
Start
1240147/1139994 (Hg38)
End
1240147/1139994 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Downstream/153924;
Nearest TSS
ENST00000429181/Upstream/149773; ENST00000481245/Downstream/72640;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/233882, chrX-CpG: 20/Downstream/62338
Nearby gene
SHOX(-620001) ; CRLF2(+74740) ;
Nearest cancer related gene
CRLF2(OG, +74740) ;
Upstream sequence
gttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggtga
Downstream sequence
ctcctcaacctcacaaagtggagggattacaggcatgagccaccatgccgggcTgtgtttcttaattaatgtctgtacgttgtttttttaacatagcggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate