VISDB Viral Integration Site DataBase

VIS ID

TVIS10011694

Fusion event

HBV-IL6R integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1293

Orient

-

Integrated sequence

GCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTT| |GTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGC

Chromosome

chr1

Cytoband

q21.3

Reference genome

Start

End

154418139/154445663 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-23a-3p ; hsa-mir-124-3p ; hsa-mir-125b-5p ; hsa-mir-98-5p ; hsa-mir-451a ; hsa-mir-34c-5p ; hsa-mir-34b-3p ; hsa-mir-34a-5p ; hsa-mir-619-5p ; hsa-mir-3619-3p ; hsa-mir-6807-5p ; hsa-mir-5095 ; hsa-mir-7151-3p ; hsa-mir-4529-5p ; hsa-mir-1292-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4793-5p ; hsa-mir-6504-3p ; hsa-mir-4438 ; hsa-mir-335-3p ; hsa-mir-5096 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-7156-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-4284 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-1184 ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-6890-3p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-7641 ; hsa-mir-2052 ; hsa-mir-4695-3p ; hsa-mir-4330 ; hsa-mir-5680 ; hsa-mir-5197-5p ; hsa-mir-1537-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-221-5p ; hsa-let-7c-3p ; hsa-let-7a-5p ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-126-5p ; hsa-mir-1277-3p ; hsa-mir-202-3p ; hsa-mir-219a-1-3p ; hsa-mir-331-5p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-4678 ; hsa-mir-4738-3p ; hsa-mir-4795-3p ; hsa-mir-495-3p ; hsa-mir-510-3p ; hsa-mir-515-5p ; hsa-mir-519d-5p ; hsa-mir-519e-5p ; hsa-mir-548ae-3p ; hsa-mir-548ah-3p ; hsa-mir-548aj-3p ; hsa-mir-548am-3p ; hsa-mir-548aq-3p ; hsa-mir-548j-3p ; hsa-mir-548x-3p ; hsa-mir-5582-3p ; hsa-mir-5688 ; hsa-mir-5695 ; hsa-mir-570-3p ; hsa-mir-630 ; hsa-mir-6509-5p ; hsa-mir-653-5p

Nearest miRNA

hsa-mir-101-1/Upstream/251920; hsa-mir-1182/Downstream/530030;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/39694, chr1-CpG: 196/Downstream/55968

Upstream sequence

cacggtgaaaccccgtctctactaaaaatacaaaaaattaggcgggtgtggtggtgggcgcctgtagtcccagctactcaggaggctgaggcaggagaat

Downstream sequence

ggcttgaacccaggaggcggagcttgcagtgagctgagtttgcgccacagcactccagcccaggcgacagagcgagactcggtctcaaaaaaaaaaaaaG