Basic Information
VIS ID
TVIS10011695
Fusion event
HBV-LOC101927164 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
-
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr1
Cytoband
q42.11
Reference genome
GRCh37/hg19
Start
224412652/224224950 (Hg38)
End
224412652/224224950 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
LOC101927164
Nearest miRNA
hsa-mir-101-1/Upstream/4024331; hsa-mir-1182/Downstream/32090;
Nearest TSS
ENST00000473358/Upstream/5337; ENST00000477413/Downstream/8339;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/40897, chr1-CpG: 37/Downstream/105077
Nearby gene
DEGS1(-31510) ; NVL(+2384) ;
Upstream sequence
gttggagtgcagtggcacgatctcggctcactgcaacctctgcctcctgagttcaagcaattctcttgcctcagcctcccgagtagctgggactacaggc
Downstream sequence
catgccaccacacccagctaatttttgtatttttagtagagacggggtttcaccatattgatcaggatggtcttgatctcttgacctcgtgatccgcccg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate