Basic Information
VIS ID
TVIS10011697
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3110
Orient
+
Integrated sequence
GGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAAT| |CGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr1
Cytoband
q42.12
Reference genome
GRCh37/hg19
Start
225667787/225480085 (Hg38)
End
225667787/225480085 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1H
Nearest miRNA
hsa-mir-101-1/Upstream/1081774; hsa-mir-1182/Downstream/441995;
Nearest TSS
ENST00000473358/Upstream/15064; ENST00000448264/Downstream/21171;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4746, chr1-CpG: 168/Downstream/172483
Nearby gene
LBR(-51230) ; ENAH(+6747) ;
Upstream sequence
tgaagcaggcggatcacctgaggttgggagtttaagaccagcctggccaacatagagaatccccatctctactaaaaatacaaaattagccgggcgtgat
Downstream sequence
ggcgtatgcctgtaatcccaggtactcgggaggctgaggtgggagaatcacttgaacccgggaggcggcggttgtggtgagccgagatcgcgccattgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate