Basic Information
VIS ID
TVIS10011698
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1450
Orient
-
Integrated sequence
TATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCC| |TGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCC
Host Sequence
Chromosome
chr1
Cytoband
q42.12
Reference genome
GRCh37/hg19
Start
225667795/225480093 (Hg38)
End
225667795/225480093 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1H
Nearest miRNA
hsa-mir-101-1/Upstream/1081782; hsa-mir-1182/Downstream/441987;
Nearest TSS
ENST00000473358/Upstream/15072; ENST00000448264/Downstream/21163;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/4754, chr1-CpG: 168/Downstream/172475
Nearby gene
LBR(-51238) ; ENAH(+6739) ;
Upstream sequence
gcggatcacctgaggttgggagtttaagaccagcctggccaacatagagaatccccatctctactaaaaatacaaaattagccgggcgtgatggcgtatg
Downstream sequence
cctgtaatcccaggtactcgggaggctgaggtgggagaatcacttgaacccgggaggcggcggttgtggtgagccgagatcgcgccattgcactccagcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate