Basic Information
VIS ID
TVIS10011699
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1704
Orient
-
Integrated sequence
GTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGC| |ATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGC
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
37987332/37521731 (Hg38)
End
37987332/37521731 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12136/Upstream/20737; hsa-mir-101-1/Downstream/567500;
Nearest TSS
ENST00000473358/Upstream/6957; ENST00000490312/Downstream/19863;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/6767, chr1-CpG: 30/Downstream/32274
Nearby gene
MEAF6(-6912) ; SNIP1(+12718) ;
Upstream sequence
ttcaagtgattctcctgcctcagcctcccaagtagctgggattacaggtatacccgccaccacacccagctaattttgtatttttagtagagacggggtt
Downstream sequence
tctccatgttggtcaggctggtcttgaactcccgacctcaggcgatctgcccaccttggcctcccaaagtgctgggattacagacgtgagccaccacgcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate