Basic Information
VIS ID
TVIS10011701
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|
Start
2848
Orient
+
Integrated sequence
TTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAG| |CATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGAC
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
End
83043455/82577772 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-101-1/Upstream/5517570; hsa-mir-11399/Downstream/2556022;
Nearby gene
LPHN2(-585348) ; MIR548AP(+1216143) ;
Upstream sequence
TCTGCTGATTATCAATTATAAACAGGAGTTGTACATGCATTTAAGTTTGGACCTTTAGGGGAATTTGTATACAAAAGATAATGTATTGGATATTTCCCTA
Downstream sequence
GCCTTTTATCATTTAAATAATATAGGGCACAGAAACAAACAAAAGCATCAGAAGTCAAAATTATCTGTAATTATCTTTGGTTTGCCTACAGCATCTGTAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate