Basic Information
VIS ID
TVIS10011702
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2298
Orient
-
Integrated sequence
ACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTAT| |AGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGAC
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
83043578/82577895 (Hg38)
End
83043578/82577895 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/5517693; hsa-mir-11399/Downstream/2555899;
Nearest TSS
ENST00000473358/Upstream/316762; ENST00000419658/Downstream/325288;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/774532, chr1-CpG: 50/Downstream/1282689
Nearby gene
LPHN2(-585471) ; MIR548AP(+1216020) ;
Upstream sequence
AGGGCACAGAAACAAACAAAAGCATCAGAAGTCAAAATTATCTGTAATTATCTTTGGTTTGCCTACAGCATCTGTATTCAGAGTGCAGATATAGGGCACT
Downstream sequence
ATGTATCATTTAATATGAAAGGCAACATCTTGGAGTTTTAGAAATTCCTGTAAGAATTTGAAAAAAAAAAAAAACTTCATGATGCCCTGCAAACAAAAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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