VISDB Viral Integration Site DataBase

VIS ID

TVIS10011703

Fusion event

HBV-ZNF644 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

3110

Orient

+

Integrated sequence

GGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAAT| |CGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG

Chromosome

chr1

Cytoband

p22.2

Reference genome

Start

End

91395708/90930151 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-34a-5p ; hsa-mir-19b-3p ; hsa-let-7d-5p ; hsa-mir-16-5p ; hsa-let-7a-5p ; hsa-mir-647 ; hsa-mir-4477a ; hsa-mir-6762-3p ; hsa-mir-604 ; hsa-mir-4716-5p ; hsa-mir-4709-5p ; hsa-mir-889-5p ; hsa-mir-7151-5p ; hsa-mir-5197-5p ; hsa-mir-19a-3p ; hsa-mir-653-3p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-3924 ; hsa-mir-1294 ; hsa-mir-548au-3p ; hsa-mir-202-3p ; hsa-mir-5684 ; hsa-mir-6868-5p ; hsa-mir-449b-5p ; hsa-mir-449a ; hsa-mir-34c-5p ; hsa-mir-98-5p ; hsa-let-7i-5p ; hsa-let-7f-5p ; hsa-mir-4458 ; hsa-let-7e-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-mir-4500 ; hsa-let-7g-5p ; hsa-mir-8081 ; hsa-mir-3157-3p ; hsa-mir-6869-5p ; hsa-mir-18b-3p ; hsa-mir-3145-3p ; hsa-mir-4735-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-155-5p ; hsa-mir-365a-3p ; hsa-mir-365b-3p ; hsa-mir-6867-3p ; hsa-mir-4436b-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-1470 ; hsa-mir-4667-3p ; hsa-mir-4762-5p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p

Nearest miRNA

hsa-mir-101-1/Upstream/4572464; hsa-mir-11399/Downstream/2916681;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/36145, chr1-CpG: 78/Downstream/91450

Upstream sequence

ccaggcgggtggatcacctaaagtcaggagttcgagaccagcctgaccaacatggagaaaccccatctctactaaaaatacaaaattagccgggcgtgat

Downstream sequence

ggcgtgtgcctgtaatcccagctactcaggaggctgagccaggagaatcacttgaacctgggaggcagaggttgcagtgagccgagactgcaccattgca