Basic Information
VIS ID
TVIS10011704
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1445
Orient
-
Integrated sequence
TGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTG| |AATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGG
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
71354850/69595094 (Hg38)
End
71354850/69595094 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10C
Nearest miRNA
hsa-mir-1265/Upstream/2191684; hsa-mir-107/Downstream/2195653;
Nearest TSS
ENST00000439456/Upstream/19287; ENST00000421716/Downstream/35157;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/16175, chr10-CpG: 51/Downstream/35040
Nearby gene
NEUROG3(-21640) ; FAM241B(+35153) ;
Upstream sequence
gtggatcacctgagatcaggagttcaagaccagcctggccaacatgacaaaaccctgtctgtactaaaaatacaaaaattagctgggcgtggtggcacag
Downstream sequence
gcctgtaatcccaggtactcgggaggctgaggtgggagaatcacttgagccgggaggtggaggctgaagtgaaccaagatcatgccatgcactccagcct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate