VISDB Viral Integration Site DataBase

VIS ID

TVIS10011705

Fusion event

HBV-PKNOX2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1750

Orient

-

Integrated sequence

CTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAG| |GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG

Chromosome

chr11

Cytoband

q24.2

Reference genome

Start

End

125229809/125359913 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-1185-2-3p ; hsa-mir-4665-5p ; hsa-mir-4472 ; hsa-mir-1275 ; hsa-mir-4447 ; hsa-mir-92a-2-5p ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-6785-5p ; hsa-mir-149-3p ; hsa-mir-671-5p ; hsa-mir-6783-5p ; hsa-mir-4323 ; hsa-mir-5192 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6829-3p ; hsa-mir-6823-3p ; hsa-mir-6791-3p ; hsa-mir-2114-3p ; hsa-mir-6734-3p ; hsa-mir-5193 ; hsa-mir-665

Nearest miRNA

hsa-let-7a-2/Upstream/1978401; hsa-mir-3167/Downstream/1628545;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/193134, chr11-CpG: 100/Downstream/135328

Upstream sequence

GGCTGGCTGGCACCTACTCTGCCATGTCAGGTGGAGGGCTCAGAAGAGGGGATGTCCTCTTAGGAGTGTCTGTGCTTtttttatatttttagtagagatg

Downstream sequence

gaggttctccatgttggtcaggctggtctcgaactcccgacctcaggtgatctgcccgcctcggcctcccaaagtgctgggattacaggcgtgagccacc