Basic Information
VIS ID
TVIS10011707
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1750
Orient
-
Integrated sequence
CTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAG| |GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
65756076/65988605 (Hg38)
End
65756076/65988605 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/339352; hsa-let-7a-2/Downstream/945829;
Nearest TSS
ENST00000527297/Upstream/10118; ENST00000530204/Downstream/11877;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/11810, chr11-CpG: 86/Downstream/13321
Nearby gene
SART1(-8469) ; EIF1AD(+7940) ;
Upstream sequence
TGCACCTCAATTTGGGTGCTTTCTAACTGAAAGACCAGGGCggccaggcgcggtggttcacgcctgtaatcccaaaactttgggaggccaaggcgggcag
Downstream sequence
atcgcctgaggtcgggagttcaagaccagcctgaccaacatggagaaaccccatctctactaaaaatacaaaattagccaggcgtggtggtgcgtgcctg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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