Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene741199644233706715665910678391690739699430665103666601657246658592686248687464654861655777689506690216662801662970692716
DEAF1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011708
Fusion event
HBV-DEAF1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3110
Orient
+
Integrated sequence
GGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAAT| |CGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
692716/692716 (Hg38)
End
692716/692716 (Hg38)
Orient
+
Location type
Intronic
Target gene
DEAF1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-324-5p ; hsa-mir-100-5p ; hsa-mir-25-3p ; hsa-mir-218-5p ; hsa-mir-210-3p
Nearest miRNA
hsa-mir-210/Upstream/124518; hsa-let-7a-2/Downstream/563889;
Nearest TSS
ENST00000527297/Upstream/366; ENST00000488769/Downstream/928;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/32035, chr11-CpG: 211/Downstream/1848
Upstream sequence
ccaaggcgggcggatcacctgaggtcaggagttcgagaccagcctgaccaacatagagaaaccccatctctactaaaaatacaaaattagccgggcgtgg
Downstream sequence
tggcacatgcctgtaatcccagctactcgggaggctgaggcaggagaatcacttgaacccgggaggcgggaggttgcggtgagctgagatcacaccattg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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