VISDB Viral Integration Site DataBase

VIS ID

TVIS10011710

Fusion event

HBV-ALDH1L2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1638

Orient

-

Integrated sequence

TACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAAT| |ATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAG

Chromosome

chr12

Cytoband

q23.3

Reference genome

Start

End

105469187/105075409 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-4474-3p ; hsa-mir-7108-5p ; hsa-mir-5087 ; hsa-mir-6730-3p ; hsa-mir-1976 ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-660-3p ; hsa-mir-1306-5p

Nearest miRNA

hsa-let-7i/Upstream/483693; hsa-mir-1178/Downstream/3560401;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/88742, chr12-CpG: 67/Downstream/32146

Upstream sequence

cgcggtggctcacgcctgtaatcccagcactttgggaggctgaggcgggtgaatcacctgaggtcgggagttcaagaccagcctgaccaacatggagaaa

Downstream sequence

ccctgtctctactaaaaatacaaaaattagccgggtatggtggcaggcatctgtaatcccagctactcgggaggctgaggtaggaaaattgcttgaaccc