Basic Information
VIS ID
TVIS10011712
Fusion event
HBV-CERS5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1813
Orient
-
Integrated sequence
AGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCA| |CCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGA
Host Sequence
Chromosome
chr12
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
50549756/50155973 (Hg38)
End
50549756/50155973 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
CERS5
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-mir-1244-3/Upstream/1383936; hsa-let-7i/Downstream/78169;
Nearest TSS
ENST00000382841/Upstream/11474; ENST00000551284/Downstream/11327;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/43521, chr12-CpG: 62/Downstream/10970
Upstream sequence
gggtggatcacctgtggtcaggagtttgagaccagcctgaccaatatggtgaaaccccgtctctactaaaaatacaaaaattagctgggtgtggtggcac
Downstream sequence
acctgcagtcccagctactcggaggctgaggcaggagaactgcttaaacctgggaagcagaggttgcagtgagctgagatcgcgccactgcactccagcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate