Basic Information
VIS ID
TVIS10011713
Fusion event
HBV-ATP23 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1750
Orient
-
Integrated sequence
CTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAG| |GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG
Host Sequence
Chromosome
chr12
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
58340431/57946648 (Hg38)
End
58340431/57946648 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP23
Nearest miRNA
hsa-mir-1228/Upstream/121956; hsa-let-7i/Downstream/4313711;
Nearest TSS
ENST00000382841/Upstream/4852; ENST00000546709/Downstream/3093;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/10427, chr12-CpG: 100/Downstream/973130
Upstream sequence
ccgggttcaagagattctcctgcctcagcctcctgagtagctgggattataggcgcccaccaccacccggctaattttgtatttttagtagagatggggg
Downstream sequence
gttctccatgttggtcaggctggtcttgaactcccgacctcaggtgatccacctgcctcggcctcccaaagtgctgggattacaggcgtgagccaccgcg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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