Basic Information
VIS ID
TVIS10011715
Fusion event
HBV-chr14 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1750
Orient
-
Integrated sequence
CTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAG| |GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG
Host Sequence
Chromosome
chr14
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
34947137/34477931 (Hg38)
End
34947137/34477931 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/3463189; hsa-mir-1185-1/Downstream/2474378;
Nearest TSS
ENST00000550708/Upstream/15157; ENST00000554608/Downstream/58514;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/15308, chr14-CpG: 43/Downstream/61389
Nearby gene
SPTSSA(-15669) ; EAPP(+37998) ;
Upstream sequence
gttcaagtgattctcctgcctcagcctcctgagtagctgggattacaggcatgtgccacccatgcctggctaattttgtgtttttagttgagacagggtt
Downstream sequence
tctccatgttggtcaggctggtcttgaactcccgacctcaggcgatccgccccccctcagcctcccaaagtgctgggattacaggcatgagccaccgcac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate