Basic Information
VIS ID
TVIS10011723
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
14
Orient
+
Integrated sequence
AATTCCACAACCTT| |CCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCC
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
3032502/2982501 (Hg38)
End
3032502/2982501 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/450496; hsa-mir-11401/Downstream/502880;
Nearest TSS
ENST00000527434/Upstream/910; ENST00000573315/Downstream/5755;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1548, chr16-CpG: 142/Downstream/21328
Nearby gene
PKMYT1(-1962) ; LINC00514(+6553) ;
Upstream sequence
AATGGAAATAAGTAGATGGAGCAGATAAGTGCGTGGTGTGAGGGAAACTAGGGCTGCGATCCTGCCtgccccagtttctgcgtgtgtaaaatggggataa
Downstream sequence
aaataataGTTTTctagactaggcaacatagcaaggccctgtctcaagaaagaaaaaagaaagaaaaggaagggaagaaagggaaagaaaaagagaaaga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate