VISDB Viral Integration Site DataBase

VIS ID

TVIS10011724

Fusion event

HBV-RBFOX1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1818

Orient

-

Integrated sequence

GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT

Chromosome

chr16

Cytoband

p13.3

Reference genome

Start

End

5807377/5757376 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-30a-5p ; hsa-let-7b-5p ; hsa-mir-3157-5p ; hsa-mir-153-5p ; hsa-mir-935 ; hsa-mir-4691-3p ; hsa-mir-1305 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-498 ; hsa-mir-4753-3p ; hsa-mir-627-3p ; hsa-mir-6832-3p ; hsa-mir-562

Nearest miRNA

hsa-mir-1225/Upstream/124810; hsa-mir-11401/Downstream/5549064;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/516991, chr16-CpG: 127/Downstream/261537

Nearby gene

EEF2KMT(-659588) ; RBFOX1(+261755) ;

Upstream sequence

gctggagtgcagtggtgcaatcttggttcactgcaacgcttgcctcctgggttcaagtgattctcctgcctcagcctcccgagtagctggggctacatgc

Downstream sequence

ccatgccaccacacccagctaatttttgtatttttagtagagacggggtttcaccattttggccgggatggtctcgatctcttgaccttgtgatctgccc