VISDB Viral Integration Site DataBase

VIS ID

TVIS10011728

Fusion event

HBV-OPA3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1293

Orient

-

Integrated sequence

GCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTT| |GTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGC

Chromosome

chr19

Cytoband

q13.32

Reference genome

Start

End

46036558/45533300 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-1229-3p ; hsa-mir-484 ; hsa-mir-3615 ; hsa-mir-6516-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-455-3p ; hsa-mir-500a-3p ; hsa-mir-6807-5p ; hsa-mir-4650-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-661 ; hsa-mir-6499-3p ; hsa-mir-767-5p ; hsa-mir-98-5p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6823-3p ; hsa-mir-4537 ; hsa-mir-2114-3p ; hsa-mir-5186 ; hsa-mir-3192-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-6831-5p ; hsa-mir-3927-3p ; hsa-mir-495-5p ; hsa-mir-542-3p ; hsa-mir-4504 ; hsa-mir-4764-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4462 ; hsa-mir-1252-5p ; hsa-mir-4501 ; hsa-mir-1265 ; hsa-mir-7849-3p ; hsa-mir-640 ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-378a-5p ; hsa-mir-4680-5p ; hsa-mir-4635 ; hsa-mir-3922-3p ; hsa-mir-3653-5p ; hsa-mir-3176 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-3620-3p ; hsa-mir-125a-3p ; hsa-mir-504-5p ; hsa-mir-6878-3p ; hsa-mir-4757-5p ; hsa-mir-6744-3p ; hsa-mir-6778-3p ; hsa-mir-6836-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-136-5p ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-6747-3p ; hsa-mir-6769b-3p ; hsa-mir-3183 ; hsa-mir-4723-3p ; hsa-mir-6752-3p ; hsa-mir-1910-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p

Nearest miRNA

hsa-mir-10395/Upstream/96596; hsa-let-7e/Downstream/105694;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/3703, chr19-CpG: 31/Downstream/20225

Upstream sequence

ttcttttttttttaaggcggagtctcactctgacgcccaggctggagtgcagtggcgcatctctgctcactgcaagctccgcctcctgggttcaagccat

Downstream sequence

tctcctgcctcagcctcccgagtagctgggactacaggcatttgccactatgcccggctaatattttgtatttttagtagagatggggtttcaccaagtt