Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011736
Fusion event
HBV-PIGU integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|
Start
1750
Orient
-
Integrated sequence
CTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAG| |GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG
Host Sequence
Chromosome
chr20
Cytoband
q11.22
Reference genome
Start
End
33262879/34675075 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-103a-2/Upstream/208657; hsa-mir-1-1/Downstream/315301;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/115135, chr20-CpG: 34/Downstream/2062
Nearest cancer related gene
PIGU(OG, No orient, 0)
Upstream sequence
tggcggctcacacctgtaatcccagcactttgggaggccgaggaaggcagatcacctgaggtcgggagttcaagaccagcctgaccaacatggagaaccc
Downstream sequence
ctgtctctactaaaaatacaaaattagccaggcatggtggtgcatgcctgtaatcccagctgcccaggaggctgaggcagaagaattgcttgaacccagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.