Basic Information
VIS ID
TVIS10011739
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1750
Orient
-
Integrated sequence
CTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAG| |GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG
Host Sequence
Chromosome
chr3
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
101964847/102246003 (Hg38)
End
101964847/102246003 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/2281605; hsa-mir-12124/Downstream/1278030;
Nearest TSS
ENST00000440867/Upstream/70320; ENST00000466937/Downstream/189012;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/395801, chr3-CpG: 32/Downstream/3107682
Nearby gene
LINC02085(-248077) ; ZPLD1(+189012) ;
Upstream sequence
ACTCCTCCTTCACTCTCTAACTCCTTTCACATGTTGAACTTTGTAGATTGTATCTTTGCAATCTTAAATTAGCTAGAGCCATTTCATTTTCATTGCGACT
Downstream sequence
tctcgtctctactaaaaatacaaaattagcctggcgtagtggcacatgcctgtaatcccagctactcgggaggctgaggcaggagaattgctagaaccca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate