VISDB Viral Integration Site DataBase

VIS ID

TVIS10011740

Fusion event

HBV-chr3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2239

Orient

+

Integrated sequence

GCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAG| |AAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGAC

Chromosome

chr3

Cytoband

q13.2

Reference genome

Start

End

111493984/111775137 (Hg38)

Orient

-

Location type

Intronic

Target gene

PHLDB2 ; PLCXD2

miRNAs that regulate target gene

hsa-mir-16-5p ; hsa-mir-1-3p ; hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-92a-3p ; hsa-mir-432-5p ; hsa-mir-376a-5p ; hsa-mir-382-3p ; hsa-mir-1273e ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-503-3p ; hsa-mir-6861-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-4291 ; hsa-mir-193a-5p ; hsa-mir-205-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-29c-3p ; hsa-mir-148a-3p ; hsa-mir-148b-3p ; hsa-mir-152-3p ; hsa-mir-202-5p ; hsa-mir-298 ; hsa-mir-4709-3p

Nearest miRNA

hsa-let-7g/Upstream/2172240; hsa-mir-12124/Downstream/337664;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/100440, chr3-CpG: 59/Downstream/84253

Upstream sequence

TCCTTCGATATGGCCAGTGCTCCATCCAAACTAAAATACTTTTTACTTCCTGGTTATGCACATGAATTCCAAGCTCTGTGCCTTTGTTCATGATCTATCC

Downstream sequence

atctcatgtcatcctccaaacaaccttatgagtagatactatcatcatcaccatcatttatacatggaaccaaagagcagagagatcaaAAAGAGATGAC