Basic Information
VIS ID
TVIS10011741
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1112
Orient
+
Integrated sequence
GGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTAC| |AAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGG
Host Sequence
Chromosome
chr3
Cytoband
q24
Reference genome
GRCh37/hg19
Start
147755351/148037564 (Hg38)
End
147755351/148037564 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/13599658; hsa-mir-1224/Downstream/3528312;
Nearest TSS
ENST00000440867/Upstream/97544; ENST00000490465/Downstream/40595;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/612960, chr3-CpG: 56/Downstream/660091
Nearby gene
ZIC1(-620845) ; AGTR1(+660307) ;
Nearest cancer related gene
ZIC1(TSG, -620845) ; AGTR1(TSG, +660307) ;
Upstream sequence
GTTTAATTTATTCTGTTTTGGCACTAATCACAGGCTGAATTATTTACATGGGGATAATTTTAAAATCCGTGTTTTGCACCTTCCAGACAAAATTAGAATT
Downstream sequence
TCACAGATAATAGCGACTCTTTGTTGACTAACAGTATGAAGGAAATAAGATGAGATATCTGATAGCAATTATGCAAATAGAGAGTTTGTGGTGCGCAAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate