VISDB Viral Integration Site DataBase

VIS ID

TVIS10011744

Fusion event

HBV-CCNA2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

2544

Orient

+

Integrated sequence

TCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTT| |TCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCT

Chromosome

chr4

Cytoband

q27

Reference genome

Start

End

122741372/121820217 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-24-3p ; hsa-let-7b-5p ; hsa-mir-146a-5p ; hsa-mir-193b-3p ; hsa-mir-132-3p ; hsa-mir-212-3p ; hsa-mir-98-5p ; hsa-mir-197-3p ; hsa-mir-10b-3p ; hsa-mir-130b-3p ; hsa-mir-27b-3p ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-1825 ; hsa-mir-4676-5p ; hsa-mir-575 ; hsa-mir-548e-5p ; hsa-mir-148a-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-4295 ; hsa-mir-130a-3p ; hsa-mir-301b-3p ; hsa-mir-3666 ; hsa-mir-454-3p ; hsa-mir-301a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-6835-3p ; hsa-mir-29c-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-22-3p

Nearest miRNA

hsa-mir-12113/Upstream/7163363; hsa-mir-1305/Downstream/3687042;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/18614, chr4-CpG: 71/Downstream/3185

Upstream sequence

TTGGTTTTAACCCCAATTGTTTATCCAGATGTGCTCAAAGGAGAGATGTCTTAATGGAAAAGCATGACTGAAGCATAAATGGAAACTTTCCTCAAAGAAG

Downstream sequence

ggcgcgagccaccgcacccagccTTTACTTCTTAATAAAAGAGACACTGCTTATATGCCAGAAAGTAATATTGGAAGGAAAATGTTTTAAAATTTGTAAC