VISDB Viral Integration Site DataBase

VIS ID

TVIS10011747

Fusion event

HBV-chr5 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2092

Orient

+

Integrated sequence

CTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGG| |AACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTT

Chromosome

chr5

Cytoband

q31.3

Reference genome

Start

End

139784647/140405062 (Hg38)

Orient

+

Location type

Intronic

Target gene

ANKHD1 ; ANKHD1-EIF4EBP3

miRNAs that regulate target gene

hsa-mir-424-5p ; hsa-mir-320a ; hsa-mir-185-5p ; hsa-mir-6838-5p ; hsa-mir-6834-5p ; hsa-mir-3622b-5p ; hsa-mir-885-3p ; hsa-mir-6134 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-5693 ; hsa-mir-4519 ; hsa-mir-4713-3p

Nearest miRNA

hsa-mir-10397/Upstream/2757413; hsa-mir-103a-1/Downstream/158609;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/2539, chr5-CpG: 36/Downstream/142510

Upstream sequence

gattcaattacctccctctgggtccctcctacaacatgtgggaattctgggagatacaattcaagttgagatttgggtagagacacagccaaaccatatc

Downstream sequence

GCAGAATCCATGCCTTTTGTATTTTTGAAGCTTATTGTAGAAGTCATGTGTTGGTGATTCCTACACCCACTTAGTGGTGCCTAATGTTAGAAGAGCCCCA