VISDB Viral Integration Site DataBase

VIS ID

TVIS10011748

Fusion event

HBV-chr5 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|

Start

3100

Orient

+

Integrated sequence

CATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGC| |CTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG

Chromosome

chr5

Cytoband

q31.3

Reference genome

Start

End

139784760/140405175 (Hg38)

Orient

+

Location type

Intronic

Target gene

ANKHD1 ; ANKHD1-EIF4EBP3

miRNAs that regulate target gene

hsa-mir-424-5p ; hsa-mir-320a ; hsa-mir-185-5p ; hsa-mir-6838-5p ; hsa-mir-6834-5p ; hsa-mir-3622b-5p ; hsa-mir-885-3p ; hsa-mir-6134 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-5693 ; hsa-mir-4519 ; hsa-mir-4713-3p

Nearest miRNA

hsa-mir-10397/Upstream/2757526; hsa-mir-103a-1/Downstream/158496;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/2652, chr5-CpG: 36/Downstream/142397

Upstream sequence

cctcagccttctgagtagcttggattacaggcgcccgctaccacgcctggctaatttttgtattttttagtagagacggggtttcatcatgttggccagg

Downstream sequence

ACTTATGTTTTCTGTGCCTAAAAGGATTTACAGGTTAAGAGTACATGTAGACCTCATTTTTGGAATGGAAGTTTCTAGGATACCCACTTTAGCCTAATCT