Basic Information
VIS ID
TVIS10011749
Fusion event
HBV-LOC112267855 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
-
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr5
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
139962269/140582684 (Hg38)
End
139962269/140582684 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC112267855
Nearest miRNA
hsa-mir-10397/Upstream/18933; hsa-mir-103a-1/Downstream/65160;
Nearest TSS
ENST00000502646/Upstream/17793; ENST00000509217/Downstream/50967;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/17792, chr5-CpG: 95/Downstream/49213
Nearby gene
SLC35A4(-13586) ; CD14(+49044) ;
Upstream sequence
CCAGGAGACTCCAGGTGCCATGAGTTGGTTGTGGGGATGAGAGCAGATCTCATCTCCTGTGTTGGTCTTCTGTGGGGCCTGCTCTGCCAACCTTTGCTGT
Downstream sequence
ccatgccaccacacccagctaatttttgtatttttagtagagaaggggtttcaccatgttgaccaggctggtctcgatctcctcaccttgttatccacgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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