Basic Information
VIS ID
TVIS10011754
Fusion event
HBV-RAB44 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
46
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAG| |GCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCC
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
36693705/36725928 (Hg38)
End
36693705/36725928 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA6H
Target gene
RAB44
miRNAs that regulate target gene
hsa-mir-4535 ; hsa-mir-4776-5p ; hsa-mir-711 ; hsa-mir-6859-3p ; hsa-mir-361-3p ; hsa-mir-4691-3p ; hsa-mir-22-3p ; hsa-mir-449b-3p
Nearest miRNA
hsa-mir-1236/Upstream/103416; hsa-mir-10398/Downstream/829437;
Nearest TSS
ENST00000381078/Upstream/28118; ENST00000355190/Downstream/31453;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/41570, chr6-CpG: 147/Downstream/113177
Upstream sequence
aattacagattagtttgcattttctggaatttatacaagtcaaatcacacagtttatattcttttgtctggtttctttccttccacacaatgattttgaa
Downstream sequence
AGCTGGCCAAGAGAGGTAACAGGCACTGTATATCAGTGTGTCAGGAACCTAGGCTGAGCGTAGGGGTGCAGAGGGACAGGGAGCAGCCCTAATAACACAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate