Basic Information
VIS ID
TVIS10011756
Fusion event
HBV-LOC105379301 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1750
Orient
-
Integrated sequence
CTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAG| |GAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTG
Host Sequence
Chromosome
chr8
Cytoband
p22
Reference genome
GRCh37/hg19
Start
19001803/19144293 (Hg38)
End
19001803/19144293 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105379301
Nearest miRNA
hsa-mir-124-1/Upstream/1462636; hsa-mir-10400/Downstream/3100673;
Nearest TSS
ENST00000518652/Upstream/52560; ENST00000519185/Downstream/91384;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/129757, chr8-CpG: 42/Downstream/93153
Nearby gene
PSD3(-130607) ; LOC100128993(+39383) ;
Upstream sequence
tccagtcttcttgagtgatatctctggatgtgggagtgaaccaaatgaatagcgcctgaagcgaacccctagcaaaccacagcagccctacagaggaggg
Downstream sequence
tctccatgttggtcaggctggtcttgaactcccgacctcaggcgatccgctcacctcagccttccaaagtgctgggattataggcatgagccactgtgcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate