Basic Information
VIS ID
TVIS10011757
Fusion event
HBV-CNBD1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1293
Orient
-
Integrated sequence
GCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTT| |GTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGC
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
88048735/87036507 (Hg38)
End
88048735/87036507 (Hg38)
Orient
-
Location type
Intronic
Target gene
CNBD1
Nearest miRNA
hsa-mir-12123/Upstream/6795034; hsa-mir-10400/Downstream/4168978;
Nearest TSS
ENST00000518652/Upstream/170062; ENST00000522105/Downstream/7985;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/521463, chr8-CpG: 25/Downstream/837436
Upstream sequence
agtttgaattttcaAGTCATCCTTTTAATATATTAATATACAATACATGAATAATTTATGTATTCATGCCACGAACAATTTCTTTCTTTAATTAAATTAA
Downstream sequence
ggcttgaacccaggaggcggagcttgcagtgagcagagattgtgccactgcactccagcctgggcgacagagcgagactgcatctctaaaaaaaaaaaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate