Basic Information
VIS ID
TVIS10011758
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1488
Orient
-
Integrated sequence
TGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTC| |GTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTT
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
95721859/94709631 (Hg38)
End
95721859/94709631 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA8B
Nearest miRNA
hsa-mir-12123/Upstream/793512; hsa-mir-10400/Downstream/363280;
Nearest TSS
ENST00000518652/Upstream/3977; ENST00000519353/Downstream/10072;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/67126, chr8-CpG: 54/Downstream/9939
Nearby gene
ESRP1(-2165) ; DPY19L4(+10244) ;
Nearest cancer related gene
ESRP1(TSG, -2165) ;
Upstream sequence
AATATACAATACATGAATAATTTATGTATTCATGCCACGAACAATTTCTTTCTTTAATTAAATTAAGGGGTTGGTGAGGATGGCAGTAGGAGCCAAGTTC
Downstream sequence
tgttggtcaggctggtctcaaactcccgacctcaggtgatccacccgcctcagcctcccaaagtgctgggattacaggcgtgagccaccgcacccagccg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate