VISDB Viral Integration Site DataBase

VIS ID

TVIS10011759

Fusion event

HBV-ALDH1A1 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|

Start

1309

Orient

-

Integrated sequence

GGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAG| |GTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTG

Chromosome

chr9

Cytoband

q21.13

Reference genome

Start

End

75563798/72948882 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-140-5p ; hsa-mir-181a-5p

Nearest miRNA

hsa-mir-101-2/Upstream/2138798; hsa-let-7a-1/Downstream/11020866;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/583054, chr9-CpG: 43/Downstream/1547980

Nearest cancer related gene

ALDH1A1(OG, No orient, 0)

Upstream sequence

CAGTGCTTTcattagaataacctgagaagctttaaataacagatacctgggtcttatccctcaactatttaattagcaggatatggcacctgggcttcga

Downstream sequence

GGACAAAGGAGGTATTTGGAAGTTCATGTAGCTGAATTTGTttgttgtaagaatttaaagagataatcatgggggaaaagaagcacttcaaatcgtgcct