Basic Information
VIS ID
TVIS10011760
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2720
Orient
+
Integrated sequence
AGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAG| |TTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTC
Host Sequence
Chromosome
chr9
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
75743294/73128378 (Hg38)
End
75743294/73128378 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-2/Upstream/2318294; hsa-let-7a-1/Downstream/10841370;
Nearest TSS
ENST00000422679/Upstream/47936; ENST00000468639/Downstream/23379;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/762550, chr9-CpG: 43/Downstream/1368484
Nearby gene
ALDH1A1(-175061) ; ANXA1(+23487) ;
Nearest cancer related gene
ALDH1A1(OG, -175061) ; ANXA1(TSG, +23487) ;
Upstream sequence
tgattgcaccgctgcactgcagcctgggtgacaggacagtgttcccgcctcagcctcccaagtagccaggattacaggaacaagccaccgtgcttggcCA
Downstream sequence
ttggtttttctgagaaaactctctcACGTGGTATGGCAAGGAGAGAGGCCATTTctctttaaaggccctatctccaaaacaagtcacattctgatgtact
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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